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I received my Ph.D. degree in neuroscience from National Yang-Ming University in 2010. After one year’s military service, I worked in Lien Lab as a postdoctoral fellow. When I was a graduate student, I focused on the subunit expression and functional properties of acid-sensing ion channels (ASICs) in hippocampal interneurons by combining electrophysiological recording and single-cell RT-PCR. We found that both the subunit composition and functional properties of the ASICs are cell-type specific in hippocampal interneurons.
Recently, single-cell voltage imaging has drawn my attention. I am currently establishing relevant setups and skills. Single-cell voltage imaging provides us with an extraordinary opportunity to detect the changes of membrane potential at the subcellular domain, which is difficult to be accessed by patch-clamp recording. We believe that voltage imaging technique will be helpful for understanding information processing in neurons. |
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Dr. Ju-Yun Weng (翁儒韻 博士) |
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Contact information |
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E-mail: whindang@gmail.com |
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Education |
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B.S. Chung Shan Medical University Ph.D. National Yang-Ming University (Lien lab, 2007-2010) Postdoc Yale University |
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Publications |
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酸偵測離子孔道在海馬迴內中間神經元的細胞特異性表現 (博士論文) Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons (PhD thesis) [PDF] Chan CF*, Kuo TW*, Weng JY*, Lin YC*, Chen TY*, Cheng JK, Lien CC. Ba2+-and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J Physiol (London) 2013 Oct 1; 591(19): 4843-58. *Co-First author. [PDF] [PubMed] Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. (2012) Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J Neurosci 2013 Jan 30; 33 (5): 1828-32. [PDF] [PubMed] Weng JY, Lin YC, Lien CC. Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons. J Neurosci 2010 May 12; 30 (19): 6548-58. [PDF] [Supplemental Data] [PubMed] Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-Like Muscarinic Acetylcholine Receptors Regulate Fast-Spiking Interneuron Excitability in Rat Dentate Gyrus. Neuroscience 2010 Aug 11; 169 (1): 39-51. [PDF] [PubMed] Weng JY, Hsu TT, Sun SH. Functional characterization of P2Y1 versus P2X4 receptors in RBA-2 astrocytes: elucidate the roles of ATP release and protein kinase C. J Cell Biochem 2008 May 15;104(2):554-67. [PDF] [PubMed] Chou SY, Weng JY, Lai HL, Liao F, Sun SH, Tu PH, Dickson DW, Chern Y. Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes. J Neurosci 2008 Mar 26;28(13): 3277-90. [PDF] [PubMed] Lin CC, Huang CC, Lin KH, Cheng KH, Yang DM, Tsai YS, Ong RY, Huang YN, Kao LS. Visualization of Rab3A dissociation during exocytosis: a study by total internal reflection microscopy. J Cell Physiol 2007 May 211(2):316-26. [PDF] [PubMed] |
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Postdoctoral fellow Institute of Neuroscience School of Life Sciences |
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Biography |
