1. Huang DF, Lin CW, Yang TY, Lien CC*, Yang CH, Huang HS. An intersectional genetic approach for
simultaneous cell type-specific labelling and gene knockout in the mouse. Development. 2023 Feb 15;150(4):dev201198. doi: 10.1242/dev.201198. (Impact factor: 6.862; Rank: 5/39=11.54% in Developmental Biology)
[PDF] [PubMed]

2. Jin X, Xie J, Yeh CW, Chen JC, Cheng CJ, Lien CC*, Huang CL. WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release. J Clin Invest. 2023 Apr 18. doi: 10.1172/JCI164222. .(Impact factor: 19.477; Rank: 2/139=1.08% in Medicine, Research & Experimental) [PDF] [PubMed]


1. Chou TM, Lee ZF, Wang SJ, Lien CC*, Chen SP. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. J. Headache & Pain. 2022 Nov 12. doi: 10.1186/s10194-022-01531-8 .(Impact factor: 8.588; Rank: 24/267=8.98% in Clinical Neurology) [PDF] [PubMed] [IG news][FB news]  [季重要期刊論文] 

2. Lin YL, Yang ZS, Wong WY, Lin SC, Wang SJ, Chen SP, Cheng JK, Lu H,  Lien CC. Cellular Mechanisms Underlying Central Sensitization in a Mouse Model of Chronic Muscle Pain. eLife. 2022 Nov 15;11:e78610. doi: 10.7554/eLife.78610.(Impact factor: 8.713; Rank: 8/94=8.51% in Biology) [PDF] [PubMed] [FB news]                                                                                                                     

3. Huang PH, Yang TY, Yeh CW, Huang SM, Chang HC, Hung YF, Chu WC, Cho KH, Lu TP, Kuo PH, Lee LJ, Kuo LW, Lien CC, Cheng HJ. Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.Transl. Psychiatry. 2022 Sep 26;12(1):411. doi: 10.1038/s41398-022-02184-6. (Impact factor: 7.989; Rank: 26/257=10.12% in Psychlatry) [PDF] [PubMed]

4. Devina T, Wong YH, Hsiao CW, Li YJ, Lien CC, Cheng IH. Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein. J Neurochem. 2022 Aug 9. doi: 10.1111/jnc.15687. Online ahead of print. (Impact factor: 5.546; Rank: 72/274=26.28% in Neurosciences) [PDF] [PubMed]

5. Huang DF, Lee CY, Chou MY, Yang TY, Cao X, Hsiao YH, Wu RN, Lien CC, Huang YS, Huang HP, Gau SF, Huang HS. Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons. Proc Natl Acad Sci USA. 2022 Aug 16;119(33):e2203632119. doi: 10.1073/pnas.2203632119. (Impact factor: 12.779; Rank: 9/73=12.33% in Multidisciplinary Sciences) [PDF] [PubMed]

6. Abdulmajeed W, Wang KY, Wu JW, Ajibola MI, Cheng IH, Lien CC. Connectivity and Synaptic Features of Hilar Mossy Cells and Their Effects on Granule Cell Activity Along the Hippocampal Longitudinal Axis. J Physiol. 2022 Jul;600(14):3355-3381. doi: 10.1113/JP282804. (Impact factor: 6.228; Rank: 11/81=13.58% in Physiology) [PDF] [PubMed] [cover1] [cover2] [This article relates to]

7. Yen TY, Huang Y, MacLaren DAA, Schlesiger MI, Monyer H, Lien CC. Inhibitory projections connecting the dentate gyri in the two hemispheres support spatial and contextual memory. Cell Rep. 2022 May 17;39(7):110831. doi: 10.1016/j.celrep.2022.110831. (Impact factor: 9.423; Rank: 33/195=16.92% in Cell Biology) [PDF] [PubMed] [Chinese Graphical Summary]

8. Chen WH, Lien CC, Chen CC. Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala. Pain. 2022 Mar 1;163(3):e463-e475. doi: 10.1097/j.pain.0000000000002389. (Impact factor: 6.961; Rank: 39/273=14.29% in Neurosciences) [PDF] [PubMed]


1. Feng KL, Weng JY, Chen CC, Abubaker MB, Lin HW, Charng CC, Belle JS, Tully T, Lien CC, Chiang AS. Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila. iScience. 2021 Nov 25;24(12):103506. doi: 10.1016/j.isci.2021.103506. (co-corresponding author) (Impact factor: 5.458; Rank: 14/72=19.44% in Multidisciplinary Sciences) [PDF] [PubMed]

2. Ajibola MI, Wu JW, Abdulmajeed W, Lien CC. Hypothalamic glutamate/GABA co-transmission modulates hippocampal circuits and supports long-term potentiation. J. Neurosci. 2021 Sep 29;41(39):8181-8196. doi: 10.1523/JNEUROSCI.0410-21.2021. (Impact factor: 6.167; Rank: 52/273=19.05% in Neurosciences) [PDF] [PubMed]

3. Wang KY, Wu JW, Cheng JK, Chen CC, Wong WY, Averkin RG, Tamás G, Nakazawa K, Lien CC. Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior. Cell Rep. 2021 Sep 14;36(11):109702. doi: 10.1016/j.celrep.2021.109702. (Impact factor: 9.423; Rank: 33/195=16.92% in Cell Biology) [PubMed] [PDF] [cover] [MOST GASE]

4. Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I., Lien CC. Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus. J. Comp. Neurol. 2021 Jul 1;529(10):2658-2675. doi: 10.1002/cne.25116. (Impact factor: 3.215; Rank: 10/174=5.75% in Zoology) [PDF] [PubMed]


1. Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer's disease using patient iPSC-derived neurons. Sci. Rep. 2019 Dec 17;9(1):19301. doi: 10.1038/s41598-019-55614-9. (Impact factor: 3.998; Rank: 17/71=23.94% in Multidisciplinary Sciences) [PDF] [PubMed]

2. Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern YJ.  Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in Huntington's disease. Mov. Disord. 2019 Jun;34(6):845-857. (Co-corresponding author) (Impact factor: 8.679; Rank: 11/204=5.39% in Clinical Neurology) [PDF] [PubMed] [cover]

3. Martina M., Lien CC. (First Online: 05 February 2019) Physiological Properties of Hippocampal Neurons. In: Cutsuridis V., Graham B., Cobb S., Vida I. (eds) Hippocampal Microcircuits. Springer Series in Computational Neuroscience. Springer, Cham. (co-corresponding author) [PDF] [Link]



1. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol. Dis. 2018 Jan; 109(Pt A): 25-32. (Impact factor: 5.160; Rank: 47/267=17.6% in Neurosciences) [PDF] [PubMed]


1. Huang CY, Lien CC, Cheng CF, Yen TY, Chen CJ, Tsaur ML. K+ channel Kv3.4 is essential for axon growth by limiting the influx of Ca2+ into growth cones. J. Neurosci.  2017 April; 37(17): 4433-4449.
(Impact factor: 5.971; Rank: 30/261=11.49% in Neurosciences) [PDF] [PubMed]

2. Kuo YL, Cheng JK, Hou WH, Chang YC, Du PH, Jian JJ, Rau RH, Yang JH, Lien CC, Tsaur ML. K+ channel modulatory subunits KChIP and DPP participate in Kv4-mediated mechanical pain control. J. Neurosci.  2017 April; 37(16): 4391-4404.
(Impact factor: 5.971; Rank: 30/261=11.49% in Neurosciences) [PDF] [PubMed]      


1. Lee CT, Kao MH, Hou WH, Wei YT, Chen CL, Lien CC. Causal evidence for the role of specific GABAergic interneuron types in entorhinal recruitment of dentate granule cells. Sci. Rep. 2016 Nov; 6: 36885. (Corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [PubMed] [Supplementary Information]

2. Wu CC, Lien CC, Hou WH, Chiang PM, Tsai KJ. Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer's disease. Sci. Rep. 2016 Jun; 6: 27358.

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [PubMed]

3. Hsu TT, Lee CT, Tai MH, Lien CC. Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways. Cerebral Cortex 2016 Jun; 26(6): 2715-2727. (Corresponding author)

(Impact factor: 8.665; Rank: 16/252=6.35% in Neuroscience) [PDF] [Supporting information] [PubMed]

4. Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. Wiring specificity and synaptic diversity in the mouse lateral central amygdala. J. Neurosci. 2016 April; 36(16): 4549-4563. (Corresponding author) (Featured Article)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]; also see Editor's Commentary [PDF] [PDF (Chinese Ver.)]

5. Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC*, Chern Y. Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci. Rep. 2016 Mar; 6(22529): 1-16. (*co-corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]


1. Chiang PH, Chien TC, Chen CC, Yanagawa Y, Lien CC. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci. Rep. 2015 May; 5: 10143. (Corresponding author)

(Impact factor: 5.578; Rank: 5/56=8.93% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]

2. Lin SH, Chien YC, Chiang WW, Liu YZ, Lien CC, Chen CC. Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur. J. Neurosci. 2015 Jun; 41(12): 1553-1568.

(Impact factor: 3.181; Rank: 107/252=42.46% in Neurosciences) [PDF] [PubMed]

3. Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D mutation of Presenilin-1 reduces Pen2 interaction, increases Aβ42/Aβ40 ratio and elevates ER Ca2+ accumulation. Mol. Neurobiol. 2015 Dec; 52(3): 1835-1849.

(Impact factor: 5.137; Rank: 36/252=14.29% in Neuroscience) [PubMed]


1. Cheng CF, Cheng JK, Chen CY, Lien CC, Chu D, Wang SY, Tsaur ML. Mirror-image pain is mediated by NGF produced from tumor necrosis factor alpha-activated satellite glia after peripheral nerve injury. Pain 2014 May; 155(5): 906-920.

(Impact factor: 5.213; Rank: 2/30=6.67% in Anesthesiology) [PDF] [Supporting information] [PubMed]

2. Liu YC, Cheng JK, Lien CC. Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns. J. Neurosci. 2014 Jan 22; 34(4): 1344-1357. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]


1. Chan CF*, Kuo TW*, Weng JY*, Lin YC*, Chen TY*, Cheng JK, Lien CC. Ba2+- and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J. Physiol. 2013 Oct 1; 591(19): 4843-4858. (*: Co-First author;  Corresponding author)

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]; also see the perspective by Battefeld and Kole in the same issue; also selected as the Editor Choice in the same issue [PDF]

2. Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS ONE 2013 Jul 9; 8(7): e69019.

(Impact factor: 3.234; Rank: 8/56=14.29% in Multidisciplinary Sciences) [PDF] [Supporting information] [PubMed]

3. Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J. Neurosci. 2013 Jan 30; 33(5): 1828-1832. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]


1. Lee YC, Alexandra D, Majczenko K, Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT,  Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann. Neurol. 2012 Dec; 72(6): 859-869.

(Impact factor: 9.977; Rank: 5/192=2.6% in Clinical Neurology) [PDF] [Supporting Information] [PubMed]

2. Majumder P, Chen YT, Bose JK, Wu CC, Cheng WC, Cheng SJ, Fang YH, Chen YL, Tsai KJ, Lien CC, Shen CK. TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta. Neuropathol. 2012 Aug; 124(2): 231-245. Epub 2012 Jul 4.

(Impact factor: 10.762; Rank: 4/192=2.08% in Clinical Neurology) [PDF] [Supplementary Material] [PubMed]

3. Chiang PH*, Wu PY*, Kuo TW*, Liu YC, Chan CF, Chien TC, Cheng JK, Huang YY, Chiu CD, Lien CC. GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats. J. Neurosci. 2012 Jan 4; 32(1): 62-67. (*: Co-First author; Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]


1. Lin YC, Liu YC, Huang YY, Lien CC. High-density expression of Ca2+-permeable ASIC1a channels in NG2 glia of rat hippocampus. PLoS ONE 2010 Sep 10; 5(9): e12665-e12672. (Corresponding author)

(Impact Impact factor: 3.234; Rank: 8/56=14.29% in Multidisciplinary Sciences) [PDF] [PubMed]

2. Chu KC, Chiu CD, Hsu TT, Hsieh YM, Huang YY, Lien CC. Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K+ conductance in hippocampal astrocytes. Eur. J. Neurosci. 2010 Sep; 32(5): 725-735. (Corresponding author)

(Impact factor: 3.181; Rank: 107/252=42.46% in Neurosciences) [PDF] [Supporting Information] [PubMed]

3. Weng JY, Lin YC, Lien CC. Cell type-specific expression of acid-sensing ion channels in hippocampal interneurons. J. Neurosci. 2010 May 12; 30(19): 6548-6558. (Corresponding author)

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [Supplemental Data] [PubMed]

4. Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-Like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. Neuroscience 2010 Aug 11; 169(1): 39-51. Epub 2010 Apr 28. (Corresponding author)

(Impact factor: 3.357; Rank: 95/252=37.7% in Neurosciences) [PDF] [PubMed]


1. Liao CW, Lien CC. Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron. Neuroscience 2009 Dec 29; 164(4): 1701-1711. Epub 2009 Sep 25. (Corresponding author)

(Impact factor: 3.357; Rank: 95/252=37.7% in Neurosciences) [PDF] [PubMed]


1. Aponte Y, Lien CC, Reisinger E, Jonas P. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J. Physiol. 2006 Jul 1; 574(Pt 1): 229-243. Epub 2006 May 11.

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]

2. Lien CC, Mu Y, Vargas-Caballero M, Poo MM. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat. Neurosci. 2006 Mar; 9(3): 372-380. Epub 2006 Feb 12.

(Impact factor: 16.095; Rank: 5/252=1.98% in Neuroscience) [PDF] [Supplementary Information] [PubMed]


1. Oliver D*, Lien CC*, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science (Research Article) 2004 Apr 9; 304(5668): 265-270. Epub 2004 Mar 18. (*equal contribution).

(Impact factor: 33.611; Rank: 2/56=3.57% in Multidisciplinary Sciences) [PDF] [Supporting Online Material] [PubMed]


1. Lien CC, Jonas P. Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J. Neurosci. 2003 Mar 15; 23(6): 2058-2068.

(Impact factor: 6.344; Rank: 25/252=9.92% in Neurosciences) [PDF] [PubMed]


1. Lien CC, Martina M, Schultz J, Ehmke H, Jonas P. Gating, modulation, and subunit composition of voltage-gated K+ channels in dendritic inhibitory interneurones of rat hippocampus. J. Physiol. 2002 Jan 15; 538(Pt 2): 405-419.

(Impact factor: 5.037; Rank: 5/83=6.02% in Physiology) [PDF] [PubMed]